Graves' disease — MCCQE Part 1 MCQ

Instant feedback + full explanation. One question, done properly.

EasyThyroid DisordersGraves' diseaseMCCQE Part 1

A 28-year-old woman has palpitations, tremor, heat intolerance, 4kg weight loss x 2 months. TSH <0.01, fT4 48. Bilateral proptosis, diffuse non-tender goitre. Most appropriate initial treatment?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Methimazole (antithyroid medication)

Graves' disease: methimazole preferred over PTU (better safety, once-daily dosing). PTU reserved for first-trimester pregnancy or thyroid storm. RAI may worsen ophthalmopathy. ATD for 12-18 months.

Reference: Canadian Thyroid Guidelines