skip to main content

Stevens-Johnson syndrome/toxic epidermal necrolysis — MCCQE Part 1 MCQ

Instant feedback + full explanation. One question, done properly.

HardRashStevens-Johnson syndrome/toxic epidermal necrolysisMCCQE Part 1

A 44-year-old woman started lamotrigine 2 weeks ago and now has fever, painful dusky targetoid lesions, oral erosions and skin tenderness with early detachment. Which of the following is the most appropriate next step?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Stop the suspected drug immediately and admit for urgent specialist supportive care

Mucosal erosions, fever, skin pain and epidermal detachment after a high-risk drug suggest SJS/TEN. Immediate withdrawal of the culprit drug and urgent hospital/burn or dermatology care are essential. Urticaria is pruritic wheals without mucosal necrosis or skin detachment.

Reference: Canadian dermatology severe cutaneous adverse reaction practice; Health Canada drug safety resources