Severe hypoglycaemia — MCCQE Part 1 MCQ
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Correct answer: E — Give 100% oxygen and obtain carboxyhaemoglobin by co-oximetry
A shared indoor exposure with headache, nausea, and confusion strongly suggests carbon monoxide poisoning. Standard two-wavelength pulse oximetry cannot distinguish oxyhaemoglobin from carboxyhaemoglobin and may appear normal. High-concentration oxygen should begin immediately while carboxyhaemoglobin is measured with co-oximetry; treatment must not wait for the result. The exposure source must be controlled and the patients assessed for neurologic and cardiac injury. Poison-centre or hyperbaric consultation depends on severity, pregnancy, neurologic features, cardiac involvement, and measured concentration. Naloxone does not treat carbon monoxide, and pneumonia does not explain simultaneous illness in several exposed household members.
Reference: CDC, Clinical Guidance for Carbon Monoxide Poisoning: https://www.cdc.gov/carbon-monoxide/hcp/clinical-guidance/index.html