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Opioid overdose — MCCQE Part 1 MCQ

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EasyPoisoning/OverdoseOpioid overdoseMCCQE Part 1

A 33-year-old man is found unresponsive with pinpoint pupils and respiratory rate 6/min after using fentanyl. Oxygen saturation is 82%. Which of the following is the most appropriate immediate treatment?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Ventilatory support and naloxone

Opioid overdose causes respiratory depression and is treated immediately with airway/ventilatory support and naloxone. Urine toxicology should not delay reversal. Methadone may be used for opioid agonist treatment later, not as acute overdose reversal.

Reference: Canadian emergency medicine toxicology practice; Health Canada naloxone guidance