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Major neurocognitive disorder — MCCQE Part 1 MCQ

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ModerateMemory LossMajor neurocognitive disorderMCCQE Part 1

A 78-year-old retired teacher has 2 years of progressive short-term memory loss, missed bills and getting lost while driving. Neurological examination is non-focal; symptoms are not fluctuating. Which of the following is the most likely diagnosis?

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Correct answer: E — Major neurocognitive disorder due to Alzheimer disease

Progressive memory impairment with functional decline over years is major neurocognitive disorder, most commonly Alzheimer disease. Delirium is acute and fluctuating; normal ageing should not impair finances or navigation to this degree. Depression can mimic dementia, so screening for mood, medication effects and reversible causes remains important.

Reference: Canadian Consensus Conference on Diagnosis and Treatment of Dementia