Hodgkin lymphoma — MCCQE Part 1 MCQ

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ModerateLymphadenopathyHodgkin lymphomaMCCQE Part 1

A 24-year-old woman has painless cervical lymphadenopathy, drenching night sweats, pruritus and mediastinal widening on chest radiograph. Which of the following is the most likely diagnosis?

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Correct answer: D — Hodgkin lymphoma

Hodgkin lymphoma is the single best answer because the age, timing, examination findings and investigations in the vignette fit Hodgkin lymphoma better than the alternatives. The most tempting distractor is less appropriate because it either treats a neighbouring presentation, delays a time-critical intervention, or ignores a key discriminator in the stem. The remaining options are suboptimal because they would miss the diagnosis, use an investigation or treatment in the wrong sequence, or fail to address safety and follow-up. Canadian practice should be anchored to Canadian cancer guidance, with attention to acuity, safety-netting and local provincial pathways.

Reference: Canadian cancer guidance