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Primary hypothyroidism — MCCQE Part 1 MCQ

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ModerateFatiguePrimary hypothyroidismMCCQE Part 1

A 49-year-old woman has fatigue, constipation, cold intolerance, weight gain, bradycardia, delayed reflex relaxation, high TSH and low free T4. Which of the following is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EPrimary hypothyroidism

Primary hypothyroidism is the single best answer because the age, timing, examination findings and investigations in the vignette fit Primary hypothyroidism better than the alternatives. The most tempting distractor is less appropriate because it either treats a neighbouring presentation, delays a time-critical intervention, or ignores a key discriminator in the stem. The remaining options are suboptimal because they would miss the diagnosis, use an investigation or treatment in the wrong sequence, or fail to address safety and follow-up. Canadian practice should be anchored to Canadian thyroid disease guidance, with attention to acuity, safety-netting and local provincial pathways.

Reference: Canadian thyroid disease guidance