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MCD remission definition — RACP Paediatrics MCQ

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EasyNephrologyMCD remission definitionRACP Paediatrics

An 8-year-old has nephrotic syndrome. Renal biopsy shows minimal change disease. He responds to prednisolone within 2 weeks. At what point is he considered to have achieved remission?

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Correct answer: E — Henoch-Schönlein purpura nephritis

Remission in nephrotic syndrome is defined as urine protein:creatinine ratio <20 mg/mmol (or urine dipstick negative/trace for 3 consecutive days). This typically occurs within 2-4 weeks of starting prednisolone in steroid-sensitive minimal change disease. Early response (<2 weeks) is associated with a lower relapse risk.

Reference: RCH Melbourne – 2023 – Nephrotic Syndrome CPG; KDIGO – 2021