skip to main content

FH – statin therapy in child — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

ModerateEndocrineFH – statin therapy in childRACP Paediatrics

A 5-year-old has a total cholesterol of 9.5 mmol/L and LDL of 7.2 mmol/L. His father had a myocardial infarction at age 35. Genetic testing confirms heterozygous familial hypercholesterolaemia (LDLR mutation). What treatment should be initiated?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Statin therapy

Statin therapy is recommended for children with heterozygous familial hypercholesterolaemia (HeFH) from age 8-10 years per international guidelines. Starting doses are low with gradual titration. The target is ≥50% LDL reduction. Lifestyle modification (diet, exercise) is important but insufficient alone in FH. Regular monitoring of LFTs and CK is required.

Reference: RACP Paediatric Curriculum – Endocrine/Cardiology; Australian Therapeutic Guidelines – 2024