Hypertonic saline – non-CF bronchiectasis — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

HardRespiratoryHypertonic saline – non-CF bronchiectasisRACP Paediatrics

The child's FEV1 is declining despite optimal airway clearance and prompt exacerbation treatment. What mucolytic agent has evidence for improving lung function in non-CF bronchiectasis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Inhaled hypertonic saline

Inhaled hypertonic saline (6-7%) is the most studied mucolytic for non-CF bronchiectasis. It hydrates airway surface liquid and improves mucociliary clearance. It has evidence for reducing exacerbation frequency in adults and is increasingly used in children. Dornase alfa is NOT recommended for non-CF bronchiectasis (may worsen outcomes, unlike in CF).

Reference: RCH Melbourne – 2023 – Bronchiectasis CPG; RACP Paediatric Curriculum – Respiratory