VUS – not actionable — RACP Paediatrics MCQ

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ModerateGeneticsVUS – not actionableRACP Paediatrics

Trio exome for developmental delay finds a VUS in a gene with limited disease association evidence. What is the clinical action?

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Correct answer: E — VUS – not actionable

VUS should NOT drive clinical decisions. Counsel family it's uncertain and may be reclassified with time. Contact lab for periodic reassessment.

Reference: RACP Paediatric Curriculum – Genetics; ACMG – 2015