HLA-B*1502 – carbamazepine — RACP Paediatrics MCQ

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HardGeneticsHLA-B*1502 – carbamazepineRACP Paediatrics

A child of SE Asian descent requires carbamazepine. What PGx test is recommended?

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Correct answer: E — HLA-B*1502 before carbamazepine

HLA-B*1502 testing before carbamazepine in SE Asian patients. Carriers have markedly increased SJS/TEN risk. Avoid if positive.

Reference: Australian Therapeutic Guidelines – 2024