TPMT before azathioprine — RACP Paediatrics MCQ

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ModerateGeneticsTPMT before azathioprineRACP Paediatrics

A child is starting azathioprine for autoimmune hepatitis. What pharmacogenomic test before initiating?

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Correct answer: C — TPMT before azathioprine

TPMT genotyping/phenotyping before azathioprine. TPMT deficiency: risk of severe myelosuppression. Dose adjust or use alternative.

Reference: Australian Therapeutic Guidelines – 2024