PPHN – iNO — RACP Paediatrics MCQ

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ModerateNeonatalPPHN – iNORACP Paediatrics

A term neonate with MAS has severe PPHN (pre-post ductal difference 15%, OI >25) despite optimal ventilation. What is the first-line pulmonary vasodilator?

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Correct answer: A — Inhaled nitric oxide

iNO at 20 ppm is first-line selective pulmonary vasodilator for PPHN. Assess response within 30-60 minutes. If OI >25 despite iNO, consider ECMO.

Reference: RCH Melbourne – 2023 – PPHN CPG