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Premature adrenarche — RACP Paediatrics MCQ

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ModerateEndocrinePremature adrenarcheRACP Paediatrics

A 6-year-old girl has pubic hair (Tanner 2) and body odour but no breast development. Bone age advanced 1 year. DHEAS elevated, LH/FSH prepubertal. What is the diagnosis?

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Correct answer: A — Premature adrenarche

Isolated pubic/axillary hair and body odour with elevated DHEAS, prepubertal gonadotrophins = premature adrenarche. Exclude non-classic CAH. Benign but associated with later PCOS.

Reference: RCH Melbourne – 2023 – Pubertal Variants CPG