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Subclinical hypothyroidism – Down — RACP Paediatrics MCQ

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ModerateEndocrineSubclinical hypothyroidism – DownRACP Paediatrics

A 10-year-old with Down syndrome: TSH 8.5 (mildly elevated), normal free T4, positive anti-TPO. Asymptomatic. What is the management?

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Correct answer: E — Subclinical hypothyroidism – monitor

Subclinical hypothyroidism with positive TPO antibodies: monitor with repeat TFTs in 3-6 months. Treat if TSH >10 or symptoms develop.

Reference: RCH Melbourne – 2023 – Thyroid CPG