Premature thelarche — RACP Paediatrics MCQ

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EasyEndocrinePremature thelarcheRACP Paediatrics

A 2-year-old girl has bilateral breast development (Tanner stage 2) without any other pubertal signs. Growth velocity is normal. Bone age is not advanced. LH, FSH, and oestradiol are prepubertal. What is the most likely diagnosis?

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Correct answer: B — Premature thelarche

Isolated breast development in a girl <3 years without other pubertal signs, normal growth velocity, normal bone age, and prepubertal hormones is premature thelarche. It is a benign self-limiting condition that does not progress to precocious puberty in most cases. It may fluctuate over time. Reassurance and monitoring every 6 months is appropriate.

Reference: RCH Melbourne – 2023 – Pubertal Variants CPG; RACP Paediatric Curriculum – Endocrine