ADHD – guanfacine for tics — RACP Paediatrics MCQ

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HardNeurologyADHD – guanfacine for ticsRACP Paediatrics

A 10-year-old with ADHD and comorbid anxiety/tic disorder has not tolerated stimulant medications (worsening of tics and anxiety). What is the most appropriate non-stimulant medication?

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Correct answer: E — Guanfacine

Guanfacine (alpha-2 adrenergic agonist) is a non-stimulant option particularly useful for ADHD with comorbid tic disorders or anxiety, as it does not worsen (and may improve) these conditions. Atomoxetine (noradrenaline reuptake inhibitor) is another non-stimulant option. Guanfacine is taken once daily (extended-release formulation).

Reference: Australian Therapeutic Guidelines – 2024 – Psychotropic; RACP Paediatric Curriculum – Neurodevelopment