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PLE – Crohn disease — RACP Paediatrics MCQ

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ModerateGIPLE – Crohn diseaseRACP Paediatrics

A 15-year-old with known Crohn disease develops worsening peripheral oedema. Serum albumin is 15 g/L. Urine protein is negative. Stool alpha-1 antitrypsin clearance is elevated. Inflammatory markers are raised. What is the most likely cause of the hypoalbuminaemia?

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Correct answer: D — Crohn disease

Protein-losing enteropathy is a recognised complication of inflammatory bowel disease, particularly Crohn disease with extensive small bowel involvement. Intestinal inflammation causes increased permeability and protein loss. Treatment involves optimising IBD therapy (intensifying immunosuppression/biologics) and nutritional support.

Reference: RCH Melbourne – 2023 – IBD CPG; RACP Paediatric Curriculum – GI