skip to main content

NAS – adjunctive phenobarbitone — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

ModerateNeonatalNAS – adjunctive phenobarbitoneRACP Paediatrics

The same neonate is on oral morphine for NAS. Despite maximum morphine dosing, NAS scores remain elevated with significant vomiting and diarrhoea. What adjunctive medication can be added?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Phenobarbitone

Phenobarbitone is the most commonly used adjunct medication when opioid therapy alone is insufficient to control NAS symptoms. It is particularly useful for polydrug-exposed infants. Clonidine is an emerging alternative adjunct. The goal is to achieve symptom control with the lowest effective doses and wean gradually.

Reference: RCH Melbourne – 2023 – NAS CPG; RACP Paediatric Curriculum – Neonatology