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Drug-induced pancreatitis — RACP Paediatrics MCQ

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ModerateGIDrug-induced pancreatitisRACP Paediatrics

A 10-year-old on sodium valproate for epilepsy presents with severe epigastric pain radiating to the back, vomiting, and abdominal tenderness. Serum lipase is 5 times the upper limit of normal. What is the most likely cause of the pancreatitis?

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Correct answer: C — Drug-induced (valproate)

Sodium valproate is a well-recognised cause of drug-induced pancreatitis in children. It can occur at any time during treatment and is not dose-dependent. Management includes stopping valproate, supportive care (IV fluids, analgesia, nil by mouth initially), and switching to an alternative antiepileptic drug.

Reference: Australian Therapeutic Guidelines – 2024; RCH Melbourne – 2023 – Acute Pancreatitis CPG