skip to main content

Primary immunodeficiency — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

HardRespiratoryPrimary immunodeficiencyRACP Paediatrics

A 4-year-old has had recurrent pneumonias, chronic sinusitis, and persistent otitis media with effusion. Immunoglobulin levels show low IgG, IgA, and IgM. Lymphocyte subsets are normal. What is the most likely underlying cause?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Immunodeficiency

Recurrent sinopulmonary infections with panhypogammaglobulinaemia and normal T-cell numbers suggests a primary antibody deficiency (e.g., common variable immunodeficiency or X-linked agammaglobulinaemia). Immunology referral for further evaluation and consideration of immunoglobulin replacement therapy is essential.

Reference: RCH Melbourne – 2023 – Immunodeficiency CPG; RACP Paediatric Curriculum – Immunology