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Congenital toxoplasmosis — RACP Paediatrics MCQ

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HardNeonatalCongenital toxoplasmosisRACP Paediatrics

A newborn has microcephaly, intracranial calcifications (diffusely scattered), chorioretinitis, and hydrocephalus. Maternal serology shows seroconversion during pregnancy. What is the most likely congenital infection?

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Correct answer: E — Congenital toxoplasmosis

The classic tetrad of congenital toxoplasmosis includes chorioretinitis, hydrocephalus, intracranial calcifications (diffusely scattered, unlike periventricular in CMV), and convulsions. Maternal seroconversion during pregnancy confirms the diagnosis. Treatment is with pyrimethamine + sulfadiazine + folinic acid for 12 months.

Reference: RCH Melbourne – 2023 – Congenital Infection CPG; RACP Paediatric Curriculum – Neonatology/ID