skip to main content

Congenital CMV — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

ModerateNeonatalCongenital CMVRACP Paediatrics

A newborn is noted to be small for gestational age with hepatosplenomegaly, petechiae, and jaundice. Cranial ultrasound shows periventricular calcifications. The infant fails the newborn hearing screen bilaterally. What is the most likely congenital infection?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Congenital CMV

The combination of SGA, hepatosplenomegaly, petechiae, periventricular (not scattered) calcifications on cranial imaging, and sensorineural hearing loss is the classic presentation of symptomatic congenital CMV infection. CMV is the most common congenital infection. Diagnosis is confirmed by CMV PCR on urine or saliva within the first 3 weeks of life. Oral valganciclovir may be considered for symptomatic infection.

Reference: RCH Melbourne – 2023 – Congenital Infection CPG; RACP Paediatric Curriculum – Neonatology/ID