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Childhood absence epilepsy — RACP Paediatrics MCQ

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ModerateNeurologyChildhood absence epilepsyRACP Paediatrics

A 6-year-old girl is diagnosed with childhood absence epilepsy. What is the most appropriate first-line antiepileptic drug?

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Correct answer: B — Ethosuximide

Ethosuximide is the first-line treatment for childhood absence epilepsy per multiple guidelines. The SANAD trial demonstrated it is as effective as valproate for absence seizures with fewer side effects. Sodium valproate is an alternative, particularly if generalised tonic-clonic seizures also occur.

Reference: Australian Therapeutic Guidelines – 2024 – Neurology; RACP Paediatric Curriculum – Neurology