Follicular Lymphoma Watch Wait — RACP Adult Medicine MCQ
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Correct answer: E — Active surveillance with scheduled clinical and laboratory review
The best answer is “Active surveillance with scheduled clinical and laboratory review”. Asymptomatic low-tumour-burden follicular lymphoma can be safely observed until accepted treatment indications develop; immediate therapy has not shown a survival advantage for this presentation. Review monitors symptoms, examination and blood counts. Intensive chemotherapy, transplant, chronic steroid and splenectomy expose the patient to substantial harm without a current treatment trigger.
Reference: eviQ: R-CVP for follicular lymphoma: https://www.eviq.org.au/haematology/lymphoma/other-b-cell-lymphoma/168-r-cvp-rituximab-cyclophosphamide-vincristine