Fanconi Syndrome Bone Disease — RACP Adult Medicine MCQ
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Correct answer: E — Proximal tubular phosphate wasting (Fanconi syndrome) causing hypophosphataemia
Type 2 (proximal) RTA often coexists with Fanconi syndrome (generalised proximal tubular dysfunction): phosphaturia → hypophosphataemia → osteomalacia, glycosuria, aminoaciduria, low molecular weight proteinuria. Causes: myeloma, cystinosis, drugs (tenofovir, ifosfamide). Treatment: phosphate and alkali supplementation.
Reference: eTG – 2025 – Nephrology