Advanced HCC First-Line — RACP Adult Medicine MCQ

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ModerateMedical OncologyAdvanced HCC First-LineRACP Adult Medicine

A 65-year-old man with advanced HCC (BCLC C), Child-Pugh A. First-line systemic therapy?

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Correct answer: D — Atezolizumab + bevacizumab

IMbrave150: atezo+bev superior OS vs sorafenib. PBS-listed. Screen for varices before bevacizumab. Sorafenib/lenvatinib if ICI contraindicated.

Reference: Cancer Council – 2020; PBS – 2025