GBM Standard Treatment — RACP Adult Medicine MCQ

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ModerateMedical OncologyGBM Standard TreatmentRACP Adult Medicine

A 45-year-old man with GBM (IDH wild-type). Standard first-line treatment?

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Correct answer: D — Maximal safe resection + Stupp protocol (concurrent temozolomide + radiation, then adjuvant temozolomide)

Stupp protocol: maximal resection → concurrent TMZ + RT (60 Gy/30#) → adjuvant TMZ (6 cycles). MGMT methylation predicts TMZ response.

Reference: eTG – 2025; NCCN – 2025