PPI Hypomagnesaemia Mechanism — RACP Adult Medicine MCQ

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ModerateClinical PharmacologyPPI Hypomagnesaemia MechanismRACP Adult Medicine

A 72-year-old woman with PPI-induced hypomagnesaemia. Mechanism?

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Correct answer: C — Impaired intestinal Mg absorption via TRPM6/7 channels

PPIs impair intestinal Mg absorption via TRPM6/7 channel inhibition. Class effect, occurs with prolonged use. Causes secondary hypocalcaemia and hypokalaemia.

Reference: AMH – 2025; TGA – 2024