Ibrutinib Platelet Dysfunction — RACP Adult Medicine MCQ

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ModerateHaematologyIbrutinib Platelet DysfunctionRACP Adult Medicine

A 65-year-old man with CLL on ibrutinib. Bruising/epistaxis with NORMAL platelets, INR, APTT. Mechanism?

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Correct answer: C — Ibrutinib inhibits BTK-dependent platelet GPVI pathway

Ibrutinib inhibits platelet BTK → impaired collagen receptor signalling. Standard coag tests normal. Hold 3–7 days pre-procedure.

Reference: AMH – 2025; eTG – 2025