Anti-MDA5 Triple Therapy — RACP Adult Medicine MCQ

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HardRheumatologyAnti-MDA5 Triple TherapyRACP Adult Medicine

A 42-year-old woman with dermatomyositis develops anti-MDA5+ rapidly progressive ILD. Triple immunosuppression protocol?

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Correct answer: D — High-dose corticosteroids + calcineurin inhibitor (tacrolimus) + IV cyclophosphamide

Anti-MDA5+ RP-ILD: mortality 50–80% without aggressive Rx. Japanese triple protocol: steroids + CNI + cyclophosphamide. JAK inhibitors emerging.

Reference: eTG – 2025 – Rheumatology