Statin Myalgia Management — RACP Adult Medicine MCQ

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ModerateClinical PharmacologyStatin Myalgia ManagementRACP Adult Medicine

A 65-year-old man on statin develops myalgia with CK 800 U/L (3× ULN). LDL-C still above target on atorvastatin. Management?

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Correct answer: D — Switch to rosuvastatin at lower dose with rechallenge

CK 3–10× ULN + myalgia: withhold statin, rechallenge with different statin at lower dose. Complete cessation inappropriate post-ACS.

Reference: NHF/CSANZ – 2025; AMH – 2025