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PAMORA for OIC — RACP Adult Medicine MCQ

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ModerateClinical PharmacologyPAMORA for OICRACP Adult Medicine

A 65-year-old man with chronic pain on opioids develops constipation refractory to standard laxatives. What peripherally-acting mu-opioid receptor antagonist may help?

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Correct answer: D — Naloxegol (oral PAMORA)

Naloxegol: oral PAMORA that blocks GI mu-opioid receptors without crossing BBB. PBS-listed for OIC refractory to ≥2 laxatives.

Reference: AMH – 2025; PBS – 2025