Hereditary Spherocytosis — RACP Adult Medicine MCQ

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EasyHaematologyHereditary SpherocytosisRACP Adult Medicine

A 30-year-old man: Hb 55 g/L, reticulocytes 25%, LDH 2500, spherocytes on film, DAT NEGATIVE, positive osmotic fragility, father had splenectomy. Diagnosis?

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Correct answer: D — Hereditary spherocytosis

Spherocytes + negative DAT + positive osmotic fragility + FHx (autosomal dominant) = hereditary spherocytosis. Confirm with EMA flow cytometry.

Reference: eTG – 2025 – Haematology