ACEi ARB Angioedema Cross-React — RACP Adult Medicine MCQ

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ModerateClinical PharmacologyACEi ARB Angioedema Cross-ReactRACP Adult Medicine

A 62-year-old man with CKD 4 on ACEi develops dry cough. Switched to ARB. 2 months later: facial angioedema. ARB cross-reactivity risk for ACEi angioedema?

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Correct answer: C — ~2–8% cross-reactivity

ARBs don't directly affect bradykinin but ~2–8% cross-reactivity for angioedema exists. ARBs are still reasonable alternatives with counselling.

Reference: AMH – 2025; eTG – 2025