Difelikefalin Uraemic Pruritus — RACP Adult Medicine MCQ

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HardNephrologyDifelikefalin Uraemic PruritusRACP Adult Medicine

A 55-year-old woman on CKD5 dialysis with uraemic pruritus refractory to emollients, antihistamines, gabapentin. Emerging therapy?

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Correct answer: A — Difelikefalin (kappa-opioid agonist)

Difelikefalin: selective peripheral kappa-opioid agonist, TGA provisional approval. KALM-1/KALM-2 trials showed efficacy for uraemic pruritus.

Reference: KDIGO – 2024; AMH – 2025