FVIII Inhibitor — RACP Adult Medicine MCQ

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HardHaematologyFVIII InhibitorRACP Adult Medicine

A 55-year-old man with severe haemophilia A. Prolonged APTT not correcting with mixing study. Anti-FVIII titre 15 BU/mL. Diagnosis?

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Correct answer: C — Factor VIII inhibitor (alloantibody)

FVIII inhibitors in 20–30% of severe haemophilia A. Non-correcting mixing study = inhibitor. Bypassing agents (rFVIIa, FEIBA) for acute bleeds.

Reference: eTG – 2025 – Haematology; NBA – 2024