Schistosomiasis Hepatic — RACP Adult Medicine MCQ

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ModerateInfectious DiseasesSchistosomiasis HepaticRACP Adult Medicine

A 55-year-old man with schistosomiasis (S. mansoni): variceal bleeding, splenomegaly, but preserved hepatocellular function. Pathological hallmark?

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Correct answer: C — Pre-sinusoidal portal hypertension with preserved hepatic function

Symmers periportal fibrosis → pre-sinusoidal portal hypertension with preserved liver synthetic function (unlike cirrhosis). Praziquantel 40 mg/kg treatment.

Reference: eTG – 2025 – Antibiotic; WHO – 2022