SLE Medication Tapering — RACP Adult Medicine MCQ

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ModerateRheumatologySLE Medication TaperingRACP Adult Medicine

A 40-year-old woman with SLE on hydroxychloroquine and MMF has been in remission for 2 years. Which medication should be tapered FIRST?

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Correct answer: D — Prednisolone

Prednisolone tapered first (cumulative toxicity). HCQ should be the LAST medication reduced. Cessation of HCQ increases flare risk 2.5×.

Reference: eTG – 2025 – Rheumatology; EULAR – 2023