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SJS from Lamotrigine — RACP Adult Medicine MCQ

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ModerateDermatologySJS from LamotrigineRACP Adult Medicine

A 28-year-old woman with epilepsy on lamotrigine develops widespread rash with mucosal involvement and 5% BSA epidermal detachment 3 weeks after starting. Diagnosis?

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Correct answer: A — Stevens-Johnson syndrome

Mucocutaneous involvement with <10% BSA detachment = SJS. Lamotrigine risk mitigated by slow dose titration. Immediate cessation. Consider SCORTEN for prognosis.

Reference: eTG – 2025 – Dermatology; AMH – 2025