Hydroxyurea Leg Ulcers — RACP Adult Medicine MCQ

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ModerateHaematologyHydroxyurea Leg UlcersRACP Adult Medicine

A 65-year-old man with MPN PV on hydroxyurea develops painful leg ulcers on lateral malleoli after 8 years. Cause?

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Correct answer: A — Hydroxyurea-induced leg ulcers

Hydroxyurea-induced leg ulcers occur in ~10% with prolonged use. Lateral malleoli typical. Requires drug cessation and switch to alternative cytoreductive agent.

Reference: eTG – 2025 – Haematology; EHA – 2022