Serotonin Syndrome Treatment — RACP Adult Medicine MCQ

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ModerateClinical PharmacologySerotonin Syndrome TreatmentRACP Adult Medicine

A 60-year-old man with serotonin syndrome on duloxetine + oxycodone develops agitation, hyperthermia, myoclonus, clonus, hyperreflexia. Treatment?

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Correct answer: C — Cease serotonergic agents; supportive care; benzodiazepines; cyproheptadine for moderate-severe

Serotonin syndrome: cease serotonergic agents. Benzodiazepines for agitation/myoclonus. Cyproheptadine (5-HT2A antagonist) for moderate-severe.

Reference: AMH – 2025; eTG – 2025 – Toxicology