Myeloma Dara-VRd — RACP Adult Medicine MCQ

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ModerateHaematologyMyeloma Dara-VRdRACP Adult Medicine

A 60-year-old woman with newly diagnosed myeloma (standard risk, transplant-eligible). Standard induction regimen?

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Correct answer: B — Dara-VRd (daratumumab + bortezomib + lenalidomide + dexamethasone)

Dara-VRd is the new standard induction for transplant-eligible myeloma (GRIFFIN, PERSEUS trials). Superior MRD negativity and PFS vs VRd.

Reference: eTG – 2025 – Haematology; NCCN – 2025; PERSEUS Trial