Catastrophic APS — RACP Adult Medicine MCQ

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HardRheumatologyCatastrophic APSRACP Adult Medicine

A 35-year-old woman with APS develops CAPS (multiorgan thrombosis over 48 hours). What triple therapy?

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Correct answer: A — Anticoagulation + plasma exchange + corticosteroids

CAPS triple therapy: heparin anticoagulation + plasma exchange + high-dose IV corticosteroids. IVIg, rituximab, eculizumab for refractory.

Reference: eTG – 2025 – Haematology; CAPS Registry – 2023