Dasatinib Pleural/PAH — RACP Adult Medicine MCQ

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ModerateHaematologyDasatinib Pleural/PAHRACP Adult Medicine

A 45-year-old man with CML on dasatinib develops pleural effusions and elevated PASP 55 mmHg. Most likely drug complication?

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Correct answer: A — Dasatinib-induced pleural effusions and PAH

Dasatinib uniquely causes pleural effusions (15–35%) and PAH (0.5–5%). Switch to alternative TKI if significant.

Reference: AMH – 2025; eTG – 2025 – Haematology