Combination Neuropathic Pain — RACP Adult Medicine MCQ

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ModerateEndocrinology & DiabetesCombination Neuropathic PainRACP Adult Medicine

A 68-year-old man with diabetic neuropathy has failed pregabalin and duloxetine individually. What combination?

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Correct answer: D — Pregabalin + duloxetine combination

OPTION-DM trial: combination therapy (pregabalin + duloxetine or amitriptyline) superior to switching between monotherapies.

Reference: eTG – 2025 – Neurology; OPTION-DM – 2022