Pirfenidone Photosensitivity — RACP Adult Medicine MCQ

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EasyClinical PharmacologyPirfenidone PhotosensitivityRACP Adult Medicine

A 62-year-old man with IPF on pirfenidone develops severe sunburn after minimal sun exposure. Mechanism and management?

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Correct answer: D — Pirfenidone photosensitivity – sun avoidance, SPF 50+, dose reduction if needed

Pirfenidone causes phototoxic photosensitivity in 8–12%. Strict sun avoidance + SPF 50+. Does NOT require permanent cessation. Nintedanib alternative if unmanageable.

Reference: AMH – 2025; eTG – 2025 – Respiratory