Haemochromatosis CPPD Mechanism — RACP Adult Medicine MCQ
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Correct answer: E — Measure transferrin saturation and ferritin for haemochromatosis
The best answer is “Measure transferrin saturation and ferritin for haemochromatosis”. Haemochromatosis is a classic metabolic association of CPPD, particularly when disease is premature or accompanied by diabetes, pigmentation, liver disease or characteristic MCP involvement. Iron studies screen for systemic iron overload; genetic assessment follows when appropriate. Hyperparathyroidism, hypomagnesaemia and hypothyroidism are other selected secondary causes, but the stated phenotype points strongly to haemochromatosis.
Reference: RHD Australia: Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease: https://www.rhdaustralia.org.au/resources/2020-australian-guideline-for-prevention-diagnosis-and-management-of-acute-rheumatic-fever-and-rheumatic-heart-disease-3rd-edition