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MN Spontaneous Remission — RACP Adult Medicine MCQ

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ModerateNephrologyMN Spontaneous RemissionRACP Adult Medicine

A 65-year-old man with nephrotic syndrome and MN has spike-and-dome pattern on silver stain, anti-PLA2R positive. What percentage achieves spontaneous remission?

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Correct answer: C — ~30% (up to one-third)

~30–40% of primary MN achieves spontaneous remission, especially with subnephrotic proteinuria or declining anti-PLA2R. 3–6 month observation before immunosuppression.

Reference: KDIGO – 2021; eTG – 2025